Atheroprotective Reverse Cholesterol Transport Pathway Is Defective in Familial Hypercholesterolemia

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Atheroprotective reverse cholesterol transport pathway is defective in familial hypercholesterolemia.

OBJECTIVE Low high-density lipoprotein (HDL) cholesterol levels are frequently observed in familial hypercholesterolemia (FH) and might be associated with functional alterations of HDL particles that may influence their efficaciousness in the reverse cholesterol transport pathway. METHODS AND RESULTS We evaluated key steps of the reverse cholesterol transport, ie, cellular free cholesterol ef...

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Familial hypercholesterolemia (FH) is characterized by the accumulation of excess cholesterol in tissues including the artery wall and tendons. We describe a patient with homozygous FH who presented with asymptomatic cholesterol granuloma of the brain. The patient's plasma low-density lipoprotein cholesterol level was remarkably responsive to combination hypolipidemic therapy with statin plus e...

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ژورنال

عنوان ژورنال: Arteriosclerosis, Thrombosis, and Vascular Biology

سال: 2011

ISSN: 1079-5642,1524-4636

DOI: 10.1161/atvbaha.111.227181